THC, or d9-Tetrahydrocannabinol, is one of the many cannabinoids that we identify with cannabis. It is also one of the most popular, considering that it is what mainly causes the psychoactive effects of weed. It takes a journey through our bodies that finishes at our brains. When our cannabinoid receptor-1 (CB-1) binds with the THC, it triggers a chemical mechanism that makes us feel high.
The second cannabinoid we can easily recognize is cannabidiol or CBD. But can it get us high like THC? It really makes you wonder, since it’s in marijuana, too!
Basically, the answer is no, CBD in weed can NOT get you high. Why can’t it?
It’s like we’re doing an experiment with chemistry whenever we roll some good weed, and that’s what people often overlook. This is because the THC in different strains have varying structures, hydrophobicity (how the THC reacts around water), and electrostatics (how THC’s positive and negative charges are distributed). These are all factors which affect the tightness of the bind between THC and CB-1.
If you look at the chemical structure of both cannabinoids closely, CBD has a break in its ring structure that lets it be more flexible. It also has one more hydrogen on the oxygen part giving it an extra hydrogen bond. It also has an additional double bond. Both these added bonds cause a change in electrostatics compared to THC. For a limited time only Avid Hemp Superior CBD Products Free Shipping.
Even if the contrasts between CBD and THC are very minute, CBD bonds with CB-1 a lot more loosely than THC by threefold to fivefold.
You might think that this does no matter at all because it can still bind to CB-1, right? Well, you are wrong. Because CBD is attracted much weaker to CB-1, it has a reverse effect on this receptor compared to THC. We need to consider different viewpoints to understand how this works, because the biochemistry behind this can be particularly complicated.
Let us first take a look at how CBD is structured, which we discussed beforehand. How charge is distributed and how it is shaped differs from THC. Despite how small these variances are, it radically changes how CBD can affect CB-1.
Now let’s take a look at the cannabinoid receptor-1. This structure has been discovered quite recently. It goes with G-protein coupled receptors or GPCRs, which are a class of signalling proteins or receptors. We will quickly summarize the basic description of these, because these protein receptors have entire text books about them which you can refer to if you’re looking to do extensive research.
Throughout the cellular membrane of CB-1, there are helices that pervade it. These helices are active, and the molecules that are attracted to it and perform binding affect how they move. This is because they are tremendously delicate.
Even if CBD and THC are strikingly similar, we must remember that the helices in CB-1 are sensitive. Thus, the minute differences in the cannabinoids cause varying effects on the helices. The change in their movement cause opposite reactions that affect the cells’ signalling cascades, which are big and multiplicative. Looking for the best cbd vape oil for your vaporizer? Try the Avid Hemp CBD Vape Oil
This is just one reaction among many other interactions within the cell. You can see how complicated biochemistry is now, right? All these reactions can interact with the cognizance of people differently on a much bigger scale.
You have to understand more than chemistry, considering biology also. We have to consider even the smallest interactions within the cell, which can have huge impacts on people.
If you have any questions, feel free to leave a comment below. This is just one of a series of articles we have, explaining how CBD works and affects us.