Despite the remarkable advancements in science and understanding of Amyotrophic Lateral Sclerosis or ALS, the scientist community is still struggling to come up with an effective therapy for the disease. ALS is a progressive, fatal neurodegenerative condition that is caused by a selective loss of the motor neurons in the spinal cord, motor cortex, and the brain stem. The disease strikes at once and it mostly affect people at the age of 40 to 70 years. Every year, about 5,600 people are diagnosed with this condition. Though the exact cause of ALS remains unknown, it is attributed to inflammation, oxidative stress, and neurotoxicity in the motor neurons which impairs the ability of the brain to control or initiate muscle movements.
Currently, the conventional therapeutic aid for ALS involves a regimen of several drugs that include antioxidants, mitochondria-boosting agents, anti-inflammatory molecules, neutrophic growth factors, and TNF-alpha inhibitors that suppress the activated microglial cells.
CBD as ALS Relief Supplement
Conventional therapeutic aids for ALS work by suppressing oxidative stress and inflammation while providing neuro-protectivity. CBD has all these properties and it can be used as a monotherapy or single administration drug for improving the symptoms of ALS. Several studies have shown that CBD has antioxidant, anti-inflammatory and neuroprotective benefits. That means it can be used to prolong the survival of neuronal cells and to prevent worsening of the condition, if not its onset. In addition, CBD may help with other ALS symptoms through the promotion of bronchodilation and muscle relaxation as well as improving appetite and sleep.
How it Works
The cannabinoid activates CB1 receptors thereby exerting anti-glutamatergic action by inhibiting the release of glutamate from the presynaptic nerve terminals. This reduces postsynaptic calcium influx as well as glutamate excitotoxicity within the motor neurons. Similarly, CB2 receptors’ activation provides anti-inflammatory benefits because it influences inflammatory mechanisms that include microglial activation inhibition and subsequent reduction in the microglia-derived neurotoxic mediators. A receptor-independent mechanism exerts the antioxidant benefits of CBD. Animal studies have shown that CBD administration delays the onset of the symptoms of ALS.
Generally, several studies have suggested that CBD can be used as a therapeutic aid for ALS. That’s because CBD-based medications have shown exceptional progress in improving the symptoms of not just the symptoms, but also the disease itself. However, more research is necessary to make CBD products a standard therapeutic aid for ALS.
It’s however, critical that you talk to your physician if you intend to use CBD as a therapeutic aid for ALS. Nevertheless, we have a wide range of CBD products that you or your loved one can use to relieve ALS.